SidaGhanaV1, Main, Exploration, bibRecord, 000945

Association between Anemia and Aflatoxin B1 Biomarker Levels among Pregnant Women in Kumasi, Ghana

Identifieur interne : 000945 ( Main/Exploration ); précédent : 000944; suivant : 000946

Association between Anemia and Aflatoxin B1 Biomarker Levels among Pregnant Women in Kumasi, Ghana

Auteurs : Faisal M. B. Shuaib ; Pauline E. Jolly ; John E. Ehiri ; Yi Jiang ; William O. Ellis ; Jonathan K. Stiles ; Nelly J. Yatich ; Ellen Funkhouser ; Sharina D. Person ; Craig Wilson ; Jonathan H. Williams

Source :

The American Journal of Tropical Medicine and Hygiene [ 0002-9637 ] ; 2010.

RBID : PMC:2963973

Abstract

Aflatoxins are fungal metabolites that contaminate staple food crops in many developing countries. Up to 40% of women attending a prenatal clinic in Africa may be anemic. In a cross-sectional study of 755 pregnant women, Aflatoxin B₁-lysine adducts (AF-ALB) levels were determined by high-performance liquid chromatography. Participants were divided into quartiles “low,” “moderate,” “high,” and “very high.” Anemia was defined as hemoglobin levels < 11 g/dL. Logistic regression was used to examine the association of anemia with AF-ALB. The mean AF-ALB level was 10.9 pg/mg (range = 0.44–268.73 pg/mg); 30.3% of participants were anemic. The odds of being anemic increased 21% (odds ratio [OR], 1.21, P = 0.01) with each quartile of AF-ALB reaching an 85% increased odds in the “very high” compared with the “low” category (OR, 1.85; confidence interval [CI], 1.16–2.95). This association was stronger among women with malaria and findings were robust when women with evidence of iron deficiency anemia were excluded. This study found a strong, consistent association between anemia in pregnancy and aflatoxins.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963973

DOI: 10.4269/ajtmh.2010.09-0772
PubMed: 21036841
PubMed Central: 2963973

Affiliations:

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Association between Anemia and Aflatoxin B1 Biomarker Levels among Pregnant Women in Kumasi, Ghana

Association between Anemia and Aflatoxin B1 Biomarker Levels among Pregnant Women in Kumasi, Ghana

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Abstract

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